InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2000 and 2004 by a US stock, returning 8,020,800%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2000-2004	8,020,800%
Hirequest (HQI)	2000-2004	4,127,500%
Inseego (INSG)	2000-2004	323,400%
Houston American Energy (HUSA)	2000-2004	244,859.25%
NextTrip (NTRP)	2000-2004	191,900%
ImmunoPrecise Antibodies (HYFT)	2000-2004	85,614.29%
Insmed (INSM)	2000-2004	28,508.58%
Xcel Brands (XELB)	2000-2004	28,400%
Interlink Electronics (LINK)	2000-2004	14,477.74%
Gladstone Capital (GLAD)	2000-2004	11,100.99%
Oramed Pharmaceuticals (ORMP)	2000-2004	8,275.95%
First Majestic Silver (AG)	2000-2004	7,265.33%
Americas Silver (USAS)	2000-2004	7,005.26%
Axon Enterprise (AXON)	2000-2004	5,326.02%
TherapeuticsMD (TXMD)	2000-2004	4,950.01%
Flexible Solutions International (FSI)	2000-2004	3,266.33%
American Vanguard (AVD)	2000-2004	2,306.11%
Oragenics (OGEN)	2000-2004	2,267.42%
Versus Systems Inc. (VS)	2000-2004	2,200%
Meritage (MTH)	2000-2004	1,996.67%
Cheniere Energy (LNG)	2000-2004	1,795.79%
Deckers Outdoor (DECK)	2000-2004	1,690.53%
NVR (NVR)	2000-2004	1,511.31%
China Yuchai International (CYD)	2000-2004	1,508.22%
Companhia Siderurgica Nacional ADR (SID)	2000-2004	1,498.77%