50 best performing large stocks oct 2025 to dec 2025

EXACT Sciences (EXAS) has had the highest return between October 1, 2025 and December 31, 2025 by a large-cap US stock, returning 85.6%.

ASSETDATE% RETURN
EXACT Sciences (EXAS)
10/1/2025 - 12/31/2025
85.56%
Lumentum (LITE)
10/1/2025 - 12/31/2025
82.91%
Guardant Health (GH)
10/1/2025 - 12/31/2025
74.15%
Revolution Medicines (RVMD)
10/1/2025 - 12/31/2025
63.99%
Avidity Biosciences  (RNA)
10/1/2025 - 12/31/2025
61.77%
Globus Medical (GMED)
10/1/2025 - 12/31/2025
59.35%
Albemarle (ALB)
10/1/2025 - 12/31/2025
52.81%
Natera (NTRA)
10/1/2025 - 12/31/2025
47.7%
Eli Lilly and (LLY)
10/1/2025 - 12/31/2025
45.63%
Insmed (INSM)
10/1/2025 - 12/31/2025
44.45%
YPF Sociedad Anonima (YPF)
10/1/2025 - 12/31/2025
44.36%
Symbotic (SYM)
10/1/2025 - 12/31/2025
44.08%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)
10/1/2025 - 12/31/2025
41.83%
Coherent (COHR)
10/1/2025 - 12/31/2025
41.73%
Korea Electric Power Corp ADR (KEP)
10/1/2025 - 12/31/2025
38.91%
Coca-Cola Consolidated (COKE)
10/1/2025 - 12/31/2025
38.66%
Regeneron Pharmaceuticals (REGN)
10/1/2025 - 12/31/2025
38.09%
Roivant Sciences (ROIV)
10/1/2025 - 12/31/2025
37.87%
Waters (WAT)
10/1/2025 - 12/31/2025
37.21%
Cardinal Health (CAH)
10/1/2025 - 12/31/2025
37.17%
Jazz Pharmaceuticals (JAZZ)
10/1/2025 - 12/31/2025
36.63%
Illumina (ILMN)
10/1/2025 - 12/31/2025
36.51%
Tower Semiconductor (TSEM)
10/1/2025 - 12/31/2025
36.47%
BridgeBio Pharma (BBIO)
10/1/2025 - 12/31/2025
36.17%
Ciena (CIEN)
10/1/2025 - 12/31/2025
36.05%
Large-cap stocks are treated as having a market cap of $10B+.