NVIDIA (NVDA) has had the highest return between 2019 and 2025 by a mega-cap US stock, returning 5,738.2%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2019-2025	5,738.17%
Tesla (TSLA)	2019-2025	2,049.75%
Palantir Technologies Inc Class A Common Stock (PLTR)	2019-2025	1,735.6%
Broadcom (AVGO)	2019-2025	1,572.45%
Advanced Micro Devices (AMD)	2019-2025	1,207.94%
Taiwan Semiconductor Manufacturing (TSM)	2019-2025	881.32%
Applovin (APP)	2019-2025	799.57%
GE Aerospace (GE)	2019-2025	772.62%
Eli Lilly and (LLY)	2019-2025	708.45%
Oracle (ORCL)	2019-2025	618.88%
Apple (AAPL)	2019-2025	600.22%
ASML Holding NV ADR (ASML)	2019-2025	585.31%
Micron Technology (MU)	2019-2025	549.53%
Microsoft (MSFT)	2019-2025	463.08%
Facebook (META)	2019-2025	459.94%
Goldman Sachs (GS)	2019-2025	453.45%
Costco Wholesale (COST)	2019-2025	403.24%
Morgan Stanley (MS)	2019-2025	392.98%
Alphabet Inc Class A (GOOGL)	2019-2025	379.57%
Caterpillar (CAT)	2019-2025	370.36%
Netflix (NFLX)	2019-2025	368.32%
JPMorgan Chase (JPM)	2019-2025	285.56%
American Express (AXP)	2019-2025	277.86%
Walmart (WMT)	2019-2025	273.23%
T-Mobile US (TMUS)	2019-2025	271.2%

Mega-cap stocks are treated as having a market cap of $200B+.