Seaport Therapeutics, Inc Common Stock (SPTX) has had the highest return this year by a small-cap US stock, returning 249,000%.

ASSET	YEAR	% RETURN
Seaport Therapeutics, Inc Common Stock (SPTX)	2026	249,000%
G Willi-Food International (WILC)	2026	31,135.15%
Mega Fortune Company Limited Ordinary Shares (MGRT)	2026	1,342.45%
Adlai Nortye Ltd American Depositary Shares (ANL)	2026	875.7%
Roma Green Finance Limited Ordinary Shares (ROMA)	2026	434.89%
agilon health (AGL)	2026	398.32%
BUUU (BUUU)	2026	367.61%
Q32 Bio (QTTB)	2026	311.82%
Talkspace (TALK)	2026	303.05%
RF Acquisition Corp II Ordinary Shares (RFAI)	2026	300%
Anterix (ATEX)	2026	297.48%
Faeth Therapeutics (FTH)	2026	277.97%
Climb Bio (CLYM)	2026	267.07%
Eton Pharmaceuticals (ETON)	2026	267.06%
First Tracks Biotherapeutics (TRAX)	2026	258.8%
Quantum (QMCO)	2026	238.99%
Kosmos Energy (KOS)	2026	220.81%
Nuvectis Pharma (NVCT)	2026	211.46%
Avita Medical (RCEL)	2026	208.31%
Rackspace Technology (RXT)	2026	206.3%
Bandwidth (BAND)	2026	206.18%
Entravision Communications (EVC)	2026	193.11%
Alpha Tau Medical (DRTS)	2026	186.6%
Forte Biosciences (FBRX)	2026	182.84%
Kelly Services B (KELYB)	2026	180.23%

Small-cap stocks are treated as having a market cap between $300M and $2B.