Hirequest (HQI) had the highest return between 2000 and 2005 by a US stock, returning 43,450,200%.

ASSET	YEARS	% RETURN
Hirequest (HQI)	2000-2005	43,450,200%
Cemtrex (CETX)	2000-2005	4,938,903.31%
Perspective Therapeutics (CATX)	2000-2005	2,416,566.67%
Alto Ingredients (ALTO)	2000-2005	794,931.49%
Houston American Energy (HUSA)	2000-2005	787,269.02%
Inseego (INSG)	2000-2005	201,733.33%
NextTrip (NTRP)	2000-2005	191,900%
DeFi Technologies (DEFT)	2000-2005	107,600%
ImmunoPrecise Antibodies (HYFT)	2000-2005	64,185.71%
NanoViricides (NNVC)	2000-2005	12,360%
Frontline (FRO)	2000-2005	9,678.39%
Xcel Brands (XELB)	2000-2005	9,400%
TherapeuticsMD (TXMD)	2000-2005	7,400.01%
Interlink Electronics (LINK)	2000-2005	5,449.74%
Dmc Global (BOOM)	2000-2005	4,728.89%
CBAK Energy Technology (CBAT)	2000-2005	4,320%
Monster Beverage (MNST)	2000-2005	3,581.39%
Protalix Biotherapeutics (PLX)	2000-2005	3,300%
Broadwind Energy (BWEN)	2000-2005	3,260.13%
Americas Silver (USAS)	2000-2005	3,136.84%
American Vanguard (AVD)	2000-2005	2,987.78%
Oramed Pharmaceuticals (ORMP)	2000-2005	2,470.84%
Flexible Solutions International (FSI)	2000-2005	2,316.43%
Clean Harbors (CLH)	2000-2005	2,263.8%
Meritage (MTH)	2000-2005	2,241.27%