Applied Digital (APLD) had the highest return in April 2018 by a large-cap US stock, returning 39%.

ASSET	MONTH	% RETURN
Applied Digital (APLD)	April 2018	39.02%
Axsome Therapeutics (AXSM)	April 2018	38.78%
Chipotle Mexican Grill (CMG)	April 2018	31.37%
Hut 8 Corp Common Stock (HUT)	April 2018	31%
Applied Opt (AAOI)	April 2018	28.51%
Baker Hughes (BKR)	April 2018	28.46%
Vicor (VICR)	April 2018	25.57%
HF Sinclair (DINO)	April 2018	24.85%
Ulta Beauty (ULTA)	April 2018	22.83%
Carpenter Technology (CRS)	April 2018	21.97%
Valero Energy (VLO)	April 2018	20.25%
Telefonaktiebolaget LM Ericsson B ADR (ERIC)	April 2018	20.22%
Natera (NTRA)	April 2018	20.06%
Occidental Petroleum (OXY)	April 2018	19.12%
Cenovus Energy (CVE)	April 2018	18.84%
Imperial Oil (IMO)	April 2018	17.78%
Ecopetrol SA ADR (EC)	April 2018	17.63%
Evercore Partners (EVR)	April 2018	16.38%
Cameco (CCJ)	April 2018	16.35%
Phillips 66 (PSX)	April 2018	16.15%
Viper Energy Ut (VNOM)	April 2018	15.96%
Canadian Natural Resources (CNQ)	April 2018	15.42%
Cytokinetics (CYTK)	April 2018	15.28%
Devon Energy (DVN)	April 2018	14.79%
Tesla (TSLA)	April 2018	14.69%

Large-cap stocks are treated as having a market cap of $10B+.