Cytokinetics (CYTK) had the highest return in April 2004 by a large-cap US stock, returning 550.4%.

ASSET	MONTH	% RETURN
Cytokinetics (CYTK)	April 2004	550.39%
Terawulf (WULF)	April 2004	32.58%
Leonardo DRS, Inc Common Stock (DRS)	April 2004	25.85%
Molina Healthcare (MOH)	April 2004	21.62%
CME (CME)	April 2004	21.11%
XPO Logistics (XPO)	April 2004	18.6%
Arrowhead Pharmaceuticals (ARWR)	April 2004	16.67%
Clean Harbors (CLH)	April 2004	16.55%
Contura Energy (CTRA)	April 2004	16.47%
eBay (EBAY)	April 2004	15.87%
Applied Industrial Technologies (AIT)	April 2004	15.77%
Ford Motor (F)	April 2004	14.32%
Williams Companies (WMB)	April 2004	13.38%
Westinghouse Air Brake Technologies (WAB)	April 2004	13.27%
Vicor (VICR)	April 2004	13.19%
Lincoln Electric (LECO)	April 2004	12.85%
Neurocrine Biosciences (NBIX)	April 2004	12.78%
O’Reilly Automotive (ORLY)	April 2004	12.59%
Penske Automotive (PAG)	April 2004	12.52%
JB Hunt Transport Services (JBHT)	April 2004	11.87%
Stryker (SYK)	April 2004	11.79%
Coca-Cola Europacific Partners (CCEP)	April 2004	11.71%
Hubbell (HUBB)	April 2004	11.71%
EMCOR (EME)	April 2004	11.41%
Marriott International (MAR)	April 2004	10.97%

Large-cap stocks are treated as having a market cap of $10B+.