Freedom (FRHC) had the highest return between 2017 and 2022 by a large-cap US stock, returning 42,241.8%.

ASSET	YEARS	% RETURN
Freedom (FRHC)	2017-2022	42,241.82%
argenx NV ADR (ARGX)	2017-2022	2,016.37%
Trade Desk (TTD)	2017-2022	1,498.22%
Leonardo DRS, Inc Common Stock (DRS)	2017-2022	956.24%
BioNTech SE (BNTX)	2017-2022	810.42%
Tesla (TSLA)	2017-2022	759.96%
Texas Pacific Land Trust (TPL)	2017-2022	759.12%
Moderna (MRNA)	2017-2022	716.45%
Shopify Inc Class A Subordinate Voting Shares (SHOP)	2017-2022	701.99%
Fortinet (FTNT)	2017-2022	699.9%
Kinsale Capital (KNSL)	2017-2022	678.83%
Insulet (PODD)	2017-2022	671.87%
DexCom (DXCM)	2017-2022	661.28%
BeiGene (ONC)	2017-2022	618.01%
Deckers Outdoor (DECK)	2017-2022	609.11%
Axon Enterprise (AXON)	2017-2022	580.04%
Paycom Soft (PAYC)	2017-2022	571.67%
LPL Financial (LPLA)	2017-2022	551.99%
Paylocity Holdng (PCTY)	2017-2022	537.96%
Cadence Design Systems (CDNS)	2017-2022	531.69%
Alnylam Pharmaceuticals (ALNY)	2017-2022	522.94%
MSCI (MSCI)	2017-2022	519.88%
HubSpot (HUBS)	2017-2022	511.27%
Molina Healthcare (MOH)	2017-2022	508.7%
MongoDB (MDB)	2017-2022	496.48%

Large-cap stocks are treated as having a market cap of $10B+.