Ferguson (FERG) had the highest return between 2010 and 2018 by a large-cap US stock, returning 39,346.6%.

ASSET	YEARS	% RETURN
Ferguson (FERG)	2010-2018	39,346.56%
Netflix (NFLX)	2010-2018	3,274.69%
Domino's Pizza Inc Common Stock (DPZ)	2010-2018	3,257.67%
Neurocrine Biosciences (NBIX)	2010-2018	2,477.98%
Cheniere Energy (LNG)	2010-2018	2,267.69%
Texas Pacific Land Trust (TPL)	2010-2018	1,777.76%
Tesla (TSLA)	2010-2018	1,651.54%
Broadcom (AVGO)	2010-2018	1,511.43%
Regeneron Pharmaceuticals (REGN)	2010-2018	1,440.84%
DexCom (DXCM)	2010-2018	1,359.2%
Ulta Beauty (ULTA)	2010-2018	1,187.47%
Transdigm (TDG)	2010-2018	1,120.6%
Align Technology (ALGN)	2010-2018	1,060.28%
HEICO (HEI.A)	2010-2018	1,039.15%
Amazon (AMZN)	2010-2018	1,002.36%
XPO Logistics (XPO)	2010-2018	996.71%
Centene (CNC)	2010-2018	977.57%
Constellation Brands Inc Class A (STZ)	2010-2018	945.57%
United Rentals (URI)	2010-2018	933.57%
Take-Two Interactive Software (TTWO)	2010-2018	911.2%
Genmab A-S (GMAB)	2010-2018	886.53%
Axon Enterprise (AXON)	2010-2018	880.94%
Illumina (ILMN)	2010-2018	863.78%
Burlington Stores (BURL)	2010-2018	856.88%
Tyler Technologies (TYL)	2010-2018	826.78%

Large-cap stocks are treated as having a market cap of $10B+.