QXO (QXO) had the highest return between 2008 and 2012 by a large-cap US stock, returning 1,791,977.8%.

ASSET	YEARS	% RETURN
QXO (QXO)	2008-2012	1,791,977.78%
Regeneron Pharmaceuticals (REGN)	2008-2012	612.2%
Ulta Beauty (ULTA)	2008-2012	484.47%
Booking (BKNG)	2008-2012	431.38%
Tractor Supply (TSCO)	2008-2012	406.79%
Dollar Tree (DLTR)	2008-2012	369.44%
Westlake Chemical (WLK)	2008-2012	359.52%
Ross Stores (ROST)	2008-2012	349.07%
First Majestic Silver (AG)	2008-2012	319.75%
XPO Logistics (XPO)	2008-2012	295.03%
Edwards Lifesciences (EW)	2008-2012	294.44%
Franco-Nevada (FNV)	2008-2012	292.2%
Transdigm (TDG)	2008-2012	291.1%
Tyler Technologies (TYL)	2008-2012	277.26%
Ambev SA ADR (ABEV)	2008-2012	274.52%
Jazz Pharmaceuticals (JAZZ)	2008-2012	256.9%
Domino's Pizza Inc Common Stock (DPZ)	2008-2012	255.96%
Generac (GNRC)	2008-2012	251.61%
Netflix (NFLX)	2008-2012	248.63%
F5 Networks (FFIV)	2008-2012	246.72%
Old Dominion Freight Line (ODFL)	2008-2012	239.77%
LyondellBasell Industries (LYB)	2008-2012	231.79%
Coca-Cola Femsa SAB de CV ADR (KOF)	2008-2012	230.88%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2008-2012	223.75%
Ecopetrol SA ADR (EC)	2008-2012	222.08%

Large-cap stocks are treated as having a market cap of $10B+.