QXO (QXO) had the highest return in April 2005 by a US stock with a market cap of $2B+, returning 450%.

ASSET	MONTH	% RETURN
QXO (QXO)	April 2005	450%
Travere Therapeutics (TVTX)	April 2005	225%
Insmed (INSM)	April 2005	47.13%
Nasdaq (NDAQ)	April 2005	36.52%
Align Technology (ALGN)	April 2005	34.5%
Riot Blockchain (RIOT)	April 2005	31.43%
Ciena (CIEN)	April 2005	30.68%
Badger Meter (BMI)	April 2005	27.63%
Avadel Pharmaceuticals (AVDL)	April 2005	24.42%
Corning (GLW)	April 2005	22.66%
Itron (ITRI)	April 2005	21.86%
Alphabet Inc Class A (GOOGL)	April 2005	21.24%
Illumina (ILMN)	April 2005	20.34%
Biomarin Pharmaceutical (BMRN)	April 2005	20.04%
Adtalem Global Education (ATGE)	April 2005	20%
Universal Display (OLED)	April 2005	19.65%
Companhia Energetica de Minas Gerais CEMIG Pref ADR (CIG)	April 2005	16.54%
Ultrapar Participacoes SA ADR (UGP)	April 2005	15.63%
RadNet (RDNT)	April 2005	15.63%
Trip Group Ltd ADR (TCOM)	April 2005	15.14%
Vicor (VICR)	April 2005	13.35%
Hologic (HOLX)	April 2005	12.77%
HNI (HNI)	April 2005	12.7%
Texas Pacific Land Trust (TPL)	April 2005	12.38%
Bancorp (TBBK)	April 2005	12.26%