SS Innovations International Inc Common Stock (SSII) had the highest return in 2022 by a small-cap US stock, returning 126,150%.

ASSET	YEAR	% RETURN
SS Innovations International Inc Common Stock (SSII)	2022	126,150%
Indivior PLC Ordinary Shares (INDV)	2022	520.37%
Ardmore Shpng (ASC)	2022	328.87%
Target Hospitality (TH)	2022	313.66%
Hallador Energy (HNRG)	2022	306.1%
Torm PLC Class A (TRMD)	2022	294.68%
HighPeak Energy (HPKEW)	2022	245.96%
Astria Therapeutics (ATXS)	2022	179.36%
Teekay Tankers (TNK)	2022	177.32%
Permian Basin Royalty Trust (PBT)	2022	166.23%
Sigma Lithium Resources (SGML)	2022	165.98%
International Seaways (INSW)	2022	159.01%
Bel Fuse B (BELFB)	2022	156.75%
Ardelyx (ARDX)	2022	154.46%
Trevi Therapeutics (TRVI)	2022	153.95%
Peabody Energy (BTU)	2022	153.79%
Alpha Metallurgical Resources (AMR)	2022	148.63%
Waterdrop Inc ADR (WDH)	2022	141.3%
Belite Bio Inc ADR (BLTE)	2022	141.16%
Tsakos Energy Navigation (TEN)	2022	138.21%
Borr Drilling (BORR)	2022	134.44%
Helix Energy Solutions (HLX)	2022	134.29%
Sabine Royalty Trust (SBR)	2022	134.22%
Biohaven Pharmaceutical (BHVN)	2022	131.33%
Hudson Technologies (HDSN)	2022	124.89%

Small-cap stocks are treated as having a market cap between $300M and $2B.