best performing biotech small cap stock last 5 years

Nutex Health (NUTX) has had the highest return between September 20, 2021 and September 20, 2026 by a small-cap US stock, returning 521,875%.

ASSETDATE% RETURN
Nutex Health (NUTX)
9/20/2021 - 9/20/2026
521,875%
Seaport Therapeutics, Inc Common Stock (SPTX)
9/20/2021 - 9/20/2026
213,800%
Mega Fortune Company Limited Ordinary Shares (MGRT)
9/20/2021 - 9/20/2026
2,957.14%
BUUU (BUUU)
9/20/2021 - 9/20/2026
1,056.25%
Eton Pharmaceuticals (ETON)
9/20/2021 - 9/20/2026
1,014.46%
Frequency Electronics (FEIM)
9/20/2021 - 9/20/2026
993.55%
Inhibrx Biosciences (INBX)
9/20/2021 - 9/20/2026
904.47%
Power Solutions International, Inc Common Stock (PSIX)
9/20/2021 - 9/20/2026
897.17%
Santacruz Silver Mining Ltd Common Shares (SCZM)
9/20/2021 - 9/20/2026
892.71%
Teekay (TK)
9/20/2021 - 9/20/2026
846.83%
M-tron Industries (MPTI)
9/20/2021 - 9/20/2026
818.38%
Tsakos Energy Navigation (TEN)
9/20/2021 - 9/20/2026
741.63%
Permian Basin Royalty Trust (PBT)
9/20/2021 - 9/20/2026
714.13%
Limbach (LMB)
9/20/2021 - 9/20/2026
709.7%
Avino Silver & Gold Mines (ASM)
9/20/2021 - 9/20/2026
678.05%
Ardmore Shpng (ASC)
9/20/2021 - 9/20/2026
639.43%
Natural Resource Partners (NRP)
9/20/2021 - 9/20/2026
626.11%
Graham (GHM)
9/20/2021 - 9/20/2026
616.14%
Innodata (INOD)
9/20/2021 - 9/20/2026
613.36%
Tat Techno (TATT)
9/20/2021 - 9/20/2026
603.89%
Hallador Energy (HNRG)
9/20/2021 - 9/20/2026
578.03%
Charming Medical Limited Class A Ordinary Shares (MCTA)
9/20/2021 - 9/20/2026
539.54%
Nordic American Tankers (NAT)
9/20/2021 - 9/20/2026
494.68%
BTQ Technologies Corp Common Stock (BTQ)
9/20/2021 - 9/20/2026
493.18%
Idaho Strategic Resources (IDR)
9/20/2021 - 9/20/2026
484.29%
Small-cap stocks are treated as having a market cap between $300M and $2B.