Zivo Bioscience (ZIVO) had the highest return in the 2000s by a US stock, returning 13,090,809.1%.

ASSET	DECADE	% RETURN
Zivo Bioscience (ZIVO)	2000s	13,090,809.09%
Cemtrex (CETX)	2000s	4,938,903.31%
India Globalization Capital (IGC)	2000s	2,299,900%
Taoping (TAOP)	2000s	1,478,398.57%
Hirequest (HQI)	2000s	929,050%
Live Ventures (LIVE)	2000s	356,364.06%
Perspective Therapeutics (CATX)	2000s	296,566.67%
NextTrip (NTRP)	2000s	159,900%
Ring Energy (REI)	2000s	133,233.33%
Inseego (INSG)	2000s	132,733.33%
Ocean Power Technologies (OPTT)	2000s	100,011.11%
ProMIS Neurosciences (PMN)	2000s	77,002.8%
Alto Ingredients (ALTO)	2000s	52,069.35%
DeFi Technologies (DEFT)	2000s	42,500%
Gladstone Capital (GLAD)	2000s	23,396.64%
Future Fintech (FTFT)	2000s	20,500%
ImmunoPrecise Antibodies (HYFT)	2000s	20,471.43%
TherapeuticsMD (TXMD)	2000s	19,503.88%
Frontline (FRO)	2000s	18,582.8%
Companhia Siderurgica Nacional ADR (SID)	2000s	12,673.16%
NanoViricides (NNVC)	2000s	11,800%
Broadwind Energy (BWEN)	2000s	9,608.39%
MEDIFAST (MED)	2000s	8,793.12%
Monster Beverage (MNST)	2000s	7,074.89%
Americas Silver (USAS)	2000s	4,794.74%