National Grid PLC ADR (NGG) had the highest return between 2003 and 2005 by a large-cap US stock, returning 545,016%.

ASSET	YEARS	% RETURN
National Grid PLC ADR (NGG)	2003-2005	545,016%
Cheniere Energy (LNG)	2003-2005	5,626.37%
Monster Beverage (MNST)	2003-2005	3,640.09%
Axon Enterprise (AXON)	2003-2005	1,962.25%
Williams Companies (WMB)	2003-2005	1,534.01%
U-Haul (UHAL)	2003-2005	1,520.76%
Bancolombia SA ADR (CIB)	2003-2005	1,334.23%
ArcelorMittal SA ADR (MT)	2003-2005	1,106.69%
Akamai Technologies (AKAM)	2003-2005	1,007.22%
Apple (AAPL)	2003-2005	901.2%
Intuitive Surgical (ISRG)	2003-2005	853.46%
Banco Bradesco SA ADR (BBD)	2003-2005	814.19%
CME (CME)	2003-2005	763.31%
Deckers Outdoor (DECK)	2003-2005	734.37%
Cameco (CCJ)	2003-2005	709.67%
Teck Resources Ltd Class B (TECK)	2003-2005	651.58%
Alamos Gold (AGI)	2003-2005	607.65%
Canadian Natural Resources (CNQ)	2003-2005	590.15%
Vale SA ADR (VALE)	2003-2005	572.55%
Tenaris SA ADR (TS)	2003-2005	565.33%
Allegheny Technologies (ATI)	2003-2005	530.04%
America Movil SAB de CV ADR (AMX)	2003-2005	528.71%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2003-2005	526.35%
Hologic (HOLX)	2003-2005	519.1%
Autodesk (ADSK)	2003-2005	504.06%

Large-cap stocks are treated as having a market cap of $10B+.