InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2003 and 2005 by a large-cap US stock, returning 9,399,400%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2003-2005	9,399,400%
National Grid PLC ADR (NGG)	2003-2005	918,806.25%
Cheniere Energy (LNG)	2003-2005	5,626.08%
Monster Beverage (MNST)	2003-2005	3,640.09%
Axon Enterprise (AXON)	2003-2005	1,962.25%
Williams Companies (WMB)	2003-2005	1,533.81%
Banco Bradesco SA ADR (BBD)	2003-2005	1,349.13%
Grupo Cibest (CIB)	2003-2005	1,334.23%
ArcelorMittal SA ADR (MT)	2003-2005	1,106.69%
Akamai Technologies (AKAM)	2003-2005	1,007.22%
Apple (AAPL)	2003-2005	901.02%
Sterling Construction (STRL)	2003-2005	861.71%
Intuitive Surgical (ISRG)	2003-2005	853.46%
Chunghwa Telecom (CHT)	2003-2005	786.56%
CME (CME)	2003-2005	763.34%
Deckers Outdoor (DECK)	2003-2005	734.37%
Cameco (CCJ)	2003-2005	709.67%
WESCO International (WCC)	2003-2005	664.41%
Teck Resources Ltd Class B (TECK)	2003-2005	660.51%
Alamos Gold (AGI)	2003-2005	607.73%
Canadian Natural Resources (CNQ)	2003-2005	590.45%
Vale SA ADR (VALE)	2003-2005	572.71%
Tenaris SA ADR (TS)	2003-2005	565.33%
Allegheny Technologies (ATI)	2003-2005	530.04%
America Movil SAB de CV ADR (AMX)	2003-2005	528.69%

Large-cap stocks are treated as having a market cap of $10B+.