Cheniere Energy (LNG) had the highest return between 2003 and 2005 by a large-cap US stock, returning 5,626.4%.

ASSET	YEARS	% RETURN
Cheniere Energy (LNG)	2003-2005	5,626.37%
Monster Beverage (MNST)	2003-2005	3,640.09%
Axon Enterprise (AXON)	2003-2005	1,962.25%
Williams Companies (WMB)	2003-2005	1,534.06%
U-Haul (UHAL)	2003-2005	1,520.76%
Banco Bradesco SA ADR (BBD)	2003-2005	1,367.2%
Bancolombia SA ADR (CIB)	2003-2005	1,334.23%
ArcelorMittal SA ADR (MT)	2003-2005	1,106.69%
Akamai Technologies (AKAM)	2003-2005	1,007.22%
Apple (AAPL)	2003-2005	901.2%
Intuitive Surgical (ISRG)	2003-2005	853.46%
CME (CME)	2003-2005	763.33%
Deckers Outdoor (DECK)	2003-2005	734.37%
Cameco (CCJ)	2003-2005	709.67%
Teck Resources Ltd Class B (TECK)	2003-2005	621.13%
Alamos Gold (AGI)	2003-2005	607.67%
Canadian Natural Resources (CNQ)	2003-2005	590.19%
Vale SA ADR (VALE)	2003-2005	572.55%
Tenaris SA ADR (TS)	2003-2005	565.35%
Allegheny Technologies (ATI)	2003-2005	530.04%
America Movil SAB de CV ADR (AMX)	2003-2005	528.71%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2003-2005	526.44%
Hologic (HOLX)	2003-2005	519.1%
Autodesk (ADSK)	2003-2005	504.06%
Nice Ltd ADR (NICE)	2003-2005	502.01%

Large-cap stocks are treated as having a market cap of $10B+.