AngloGold Ashanti (AU) had the highest return between 1996 and 1999 by a large-cap US stock, returning 5,395,600%.

ASSET	YEARS	% RETURN
AngloGold Ashanti (AU)	1996-1999	5,395,600%
VeriSign (VRSN)	1996-1999	3,625.66%
Qualcomm (QCOM)	1996-1999	3,347.08%
Amazon (AMZN)	1996-1999	3,022.48%
Jabil Circuit (JBL)	1996-1999	2,411.86%
Nokia (NOK)	1996-1999	1,948.09%
NetApp (NTAP)	1996-1999	1,561.2%
ASML Holding NV ADR (ASML)	1996-1999	1,223.65%
Cisco Systems (CSCO)	1996-1999	1,194.11%
MicroStrategy (MSTR)	1996-1999	1,192.31%
Best Buy (BBY)	1996-1999	1,136.89%
Telefonica SA ADR (TEF)	1996-1999	1,069.52%
Dycom Industries (DY)	1996-1999	1,049.44%
F5 Networks (FFIV)	1996-1999	1,012.2%
Cognizant Technology Solutions Corp Class A (CTSH)	1996-1999	993.12%
Microsoft (MSFT)	1996-1999	962.86%
Biogen (BIIB)	1996-1999	955.02%
Oracle (ORCL)	1996-1999	784.67%
Infosys Ltd ADR (INFY)	1996-1999	783.25%
Charles Schwab (SCHW)	1996-1999	776.1%
Check Point Software Technologies (CHKP)	1996-1999	728.13%
Texas Instruments (TXN)	1996-1999	674.54%
Vodafone Group PLC ADR (VOD)	1996-1999	667.53%
STMicroelectronics NV ADR (STM)	1996-1999	648.63%
Expeditors International of Washington (EXPD)	1996-1999	631.15%

Large-cap stocks are treated as having a market cap of $10B+.