QXO (QXO) had the highest return between 2010 and 2015 by a large-cap US stock, returning 3,068,850%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2015	3,068,850%
Regeneron Pharmaceuticals (REGN)	2010-2015	2,139.57%
Neurocrine Biosciences (NBIX)	2010-2015	1,942.24%
Jazz Pharmaceuticals (JAZZ)	2010-2015	1,643.92%
Cheniere Energy (LNG)	2010-2015	1,389.98%
Domino's Pizza Inc Common Stock (DPZ)	2010-2015	1,363.15%
Netflix (NFLX)	2010-2015	1,342.19%
Tesla (TSLA)	2010-2015	1,163.18%
Incyte (INCY)	2010-2015	1,076.25%
DexCom (DXCM)	2010-2015	897.56%
Ulta Beauty (ULTA)	2010-2015	872.8%
Constellation Brands Inc Class A (STZ)	2010-2015	795.84%
Tyler Technologies (TYL)	2010-2015	769.43%
Broadcom (AVGO)	2010-2015	760.76%
Dycom Industries (DY)	2010-2015	760.52%
Genmab A-S (GMAB)	2010-2015	702.51%
Monster Beverage (MNST)	2010-2015	670.63%
United Rentals (URI)	2010-2015	631.25%
Transdigm (TDG)	2010-2015	590.44%
Tractor Supply (TSCO)	2010-2015	575.26%
NXP Semiconductors (NXPI)	2010-2015	548.08%
O’Reilly Automotive (ORLY)	2010-2015	545.73%
Illumina (ILMN)	2010-2015	516.81%
Centene (CNC)	2010-2015	515.05%
Booking (BKNG)	2010-2015	473.48%

Large-cap stocks are treated as having a market cap of $10B+.