QXO (QXO) had the highest return in April 2010 by a large-cap US stock, returning 125%.

ASSET	MONTH	% RETURN
QXO (QXO)	April 2010	125%
United Rentals (URI)	April 2010	51%
Lattice Semiconductor (LSCC)	April 2010	42.93%
Netflix (NFLX)	April 2010	34.34%
IAMGold (IAG)	April 2010	31.59%
MGM Resorts International (MGM)	April 2010	30.78%
Cheniere Energy (LNG)	April 2010	28.09%
Neurocrine Biosciences (NBIX)	April 2010	25.39%
Huntington Bancshares (HBAN)	April 2010	23.13%
Akamai Technologies (AKAM)	April 2010	22.76%
Caseys General Stores (CASY)	April 2010	22.48%
Wheaton Precious Metals (WPM)	April 2010	21.85%
Entegris (ENTG)	April 2010	21.65%
Vulcan Materials (VMC)	April 2010	20.69%
Ciena (CIEN)	April 2010	20.56%
Natwest (NWG)	April 2010	20.22%
Dycom Industries (DY)	April 2010	20%
EOG Resources (EOG)	April 2010	19.41%
Evercore Partners (EVR)	April 2010	19.31%
Chipotle Mexican Grill (CMG)	April 2010	19.1%
Autodesk (ADSK)	April 2010	18.06%
Webster Financial (WBS)	April 2010	17.99%
AerCap (AER)	April 2010	17.85%
First Majestic Silver (AG)	April 2010	17.78%
First Solar (FSLR)	April 2010	17.7%

Large-cap stocks are treated as having a market cap of $10B+.