QXO (QXO) had the highest return between 2009 and 2012 by a large-cap US stock, returning 4,032,075%.

ASSET	YEARS	% RETURN
QXO (QXO)	2009-2012	4,032,075%
Jazz Pharmaceuticals (JAZZ)	2009-2012	2,747.59%
Sirius XM (SIRI)	2009-2012	2,352.7%
Lululemon Athletica (LULU)	2009-2012	1,817.74%
Ulta Beauty (ULTA)	2009-2012	1,095.65%
Domino's Pizza Inc Common Stock (DPZ)	2009-2012	896.99%
Regeneron Pharmaceuticals (REGN)	2009-2012	828.72%
Las Vegas Sands (LVS)	2009-2012	750.32%
Cheniere Energy Partners (CQP)	2009-2012	739.38%
Booking (BKNG)	2009-2012	735.32%
Teck Resources Ltd Class B (TECK)	2009-2012	674.9%
Baidu (BIDU)	2009-2012	659.77%
Seagate Technology (STX)	2009-2012	635.01%
Tenet Healthcare (THC)	2009-2012	587.92%
Ambev SA ADR (ABEV)	2009-2012	578.95%
Cheniere Energy (LNG)	2009-2012	561.26%
Apple (AAPL)	2009-2012	525.18%
Williams-Sonoma (WSM)	2009-2012	512.88%
HF Sinclair (DINO)	2009-2012	510.95%
Starbucks (SBUX)	2009-2012	495.11%
Flutter Entertainment (FLUT)	2009-2012	481.74%
Ford Motor (F)	2009-2012	473.54%
Wheaton Precious Metals (WPM)	2009-2012	473.19%
Cooper Companies (COO)	2009-2012	461.81%
Transdigm (TDG)	2009-2012	425.22%

Large-cap stocks are treated as having a market cap of $10B+.