Harmony Gold Mining (HMY) had the best quarter in 2016 by a large-cap US stock in Q1 2016, returning 246.7%.

ASSET	QUARTER	% RETURN
Harmony Gold Mining (HMY)	Q1 2016	246.67%
Sibanye Gold Ltd ADR (SBSW)	Q1 2016	152.52%
First Majestic Silver (AG)	Q2 2016	117.98%
Coeur Mining (CDE)	Q1 2016	115.33%
AXIA Energia (AXIA)	Q2 2016	115.29%
Energy Transfer (ET)	Q2 2016	113.94%
Teck Resources Ltd Class B (TECK)	Q1 2016	107.92%
Exelixis (EXEL)	Q2 2016	97.72%
Coeur Mining (CDE)	Q2 2016	97.04%
IAMGold (IAG)	Q2 2016	93.46%
First Majestic Silver (AG)	Q1 2016	91.71%
Hecla Mining (HL)	Q2 2016	91.15%
AngloGold Ashanti (AU)	Q1 2016	89.09%
EXACT Sciences (EXAS)	Q2 2016	84.49%
Advanced Micro Devices (AMD)	Q2 2016	84.23%
Kinross Gold (KGC)	Q1 2016	83.79%
Teck Resources Ltd Class B (TECK)	Q2 2016	78.58%
Equinox Gold (EQX)	Q1 2016	78.45%
Twilio (TWLO)	Q3 2016	74.09%
Lumentum (LITE)	Q3 2016	72.53%
Kratos Defense & Security Solutions (KTOS)	Q3 2016	71.82%
Amkor Technology (AMKR)	Q3 2016	70.52%
Compania de Minas Buenaventura SAA ADR (BVN)	Q1 2016	69.59%
Banco Bradesco S/A ADR (BBDO)	Q1 2016	68.66%
Alamos Gold (AGI)	Q2 2016	68.24%

Large-cap stocks are treated as having a market cap of $10B+.