Sandisk (SNDK) has had the highest return between 2025 and 2026 by a large-cap US stock, returning 4,862.9%.

ASSET	YEARS	% RETURN
Sandisk (SNDK)	2025-2026	4,862.92%
Abivax SA American Depositary Shares (ABVX)	2025-2026	1,485.5%
Micron Technology (MU)	2025-2026	1,100.88%
Bloom Energy (BE)	2025-2026	1,023.37%
Lumentum (LITE)	2025-2026	947.12%
Western Digital (WDC)	2025-2026	937.89%
Seagate Technology (STX)	2025-2026	895.17%
ViaSat (VSAT)	2025-2026	755.91%
Nebius (NBIS)	2025-2026	704.8%
Guardant Health (GH)	2025-2026	416.51%
TTM Technologies (TTMI)	2025-2026	402.6%
AngloGold Ashanti (AU)	2025-2026	400.3%
Revolution Medicines (RVMD)	2025-2026	378.08%
Intel (INTC)	2025-2026	373.55%
Dell Technologies (DELL)	2025-2026	367.25%
Enlight Renewable Energy Ltd Ordinary Shares (ENLT)	2025-2026	357.51%
Arrowhead Pharmaceuticals (ARWR)	2025-2026	355.86%
Millicom International Cellular (TIGO)	2025-2026	350.79%
Hut 8 Corp Common Stock (HUT)	2025-2026	343.34%
IREN (IREN)	2025-2026	333.37%
Lam Research (LRCX)	2025-2026	327.81%
Tower Semiconductor (TSEM)	2025-2026	327.58%
Hecla Mining (HL)	2025-2026	314.83%
Grupo Cibest (CIB)	2025-2026	302.37%
ASE Industrial Holding Co Ltd ADR (ASX)	2025-2026	292.1%

Large-cap stocks are treated as having a market cap of $10B+.