Regencell Bioscience (RGC) has had the highest return between 2025 and 2026 by a large-cap US stock, returning 17,633.7%.

ASSET	YEARS	% RETURN
Regencell Bioscience (RGC)	2025-2026	17,633.73%
Sandisk (SNDK)	2025-2026	4,434.91%
Abivax SA American Depositary Shares (ABVX)	2025-2026	1,691.85%
Bloom Energy (BE)	2025-2026	1,205.2%
Planet Labs PBC (PL)	2025-2026	1,134.23%
Western Digital (WDC)	2025-2026	1,077.77%
Micron Technology (MU)	2025-2026	996.54%
Lumentum (LITE)	2025-2026	972.14%
Seagate Technology (STX)	2025-2026	919.5%
ViaSat (VSAT)	2025-2026	872.39%
TTM Technologies (TTMI)	2025-2026	662.99%
Nebius (NBIS)	2025-2026	640.74%
Vicor (VICR)	2025-2026	609.85%
Ciena (CIEN)	2025-2026	584.24%
IREN (IREN)	2025-2026	558%
Applied Digital (APLD)	2025-2026	523.95%
Ast Spacemobile (ASTS)	2025-2026	513.06%
Intel (INTC)	2025-2026	501.93%
Enlight Renewable Energy Ltd Ordinary Shares (ENLT)	2025-2026	494.2%
Rocket Lab USA (RKLB)	2025-2026	490.76%
Hut 8 Corp Common Stock (HUT)	2025-2026	457.54%
Tower Semiconductor (TSEM)	2025-2026	434.21%
EchoStar (SATS)	2025-2026	429.21%
Viavi Solutions (VIAV)	2025-2026	421.68%
Applied Opt (AAOI)	2025-2026	399.94%

Large-cap stocks are treated as having a market cap of $10B+.