Thomson Reuters Corporation Common Shares (TRI) had the highest return between 1999 and 2002 by a large-cap US stock, returning 21,622.1%.

ASSET	YEARS	% RETURN
Thomson Reuters Corporation Common Shares (TRI)	1999-2002	21,622.13%
Ovintiv (OVV)	1999-2002	4,469.45%
Clean Harbors (CLH)	1999-2002	857.54%
Royal Gold (RGLD)	1999-2002	614.63%
NVR (NVR)	1999-2002	584.67%
Laboratory Corporation of America (LH)	1999-2002	576.14%
Neurocrine Biosciences (NBIX)	1999-2002	552.29%
Quest Diagnostics (DGX)	1999-2002	541.14%
Qualcomm (QCOM)	1999-2002	455.19%
Gildan Activewear (GIL)	1999-2002	450.77%
Logitech International (LOGI)	1999-2002	408.48%
Cognizant Technology Solutions Corp Class A (CTSH)	1999-2002	371.74%
Hudbay Minerals (HBM)	1999-2002	348.91%
CACI International (CACI)	1999-2002	323.97%
Biogen (BIIB)	1999-2002	322.88%
AAON (AAON)	1999-2002	319.89%
Harmony Gold Mining (HMY)	1999-2002	316.38%
Ryanair Holdings PLC ADR (RYAAY)	1999-2002	309.51%
Infosys Ltd ADR (INFY)	1999-2002	302.43%
Coherent (COHR)	1999-2002	301.5%
Gold Fields Ltd ADR (GFI)	1999-2002	288.76%
East West Bancorp (EWBC)	1999-2002	287.7%
Brown & Brown (BRO)	1999-2002	283.94%
UnitedHealth (UNH)	1999-2002	282.5%
Teva Pharma Industries Ltd ADR (TEVA)	1999-2002	278.66%

Large-cap stocks are treated as having a market cap of $10B+.