InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2000 and 2004 by a large-cap US stock, returning 7,863,100%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2000-2004	7,863,100%
Eldorado Gold (EGO)	2000-2004	34,977.81%
Thomson Reuters Corporation Common Shares (TRI)	2000-2004	31,048.75%
Cheniere Energy (LNG)	2000-2004	1,795.88%
Deckers Outdoor (DECK)	2000-2004	1,690.53%
NVR (NVR)	2000-2004	1,511.31%
Clean Harbors (CLH)	2000-2004	1,138.1%
Tapestry (TPR)	2000-2004	1,028%
HF Sinclair (DINO)	2000-2004	843.09%
Altria (MO)	2000-2004	835.29%
Tractor Supply (TSCO)	2000-2004	826.51%
DaVita HealthCare Partners (DVA)	2000-2004	778.44%
Lennar (LEN)	2000-2004	775.97%
Monster Beverage (MNST)	2000-2004	750.45%
DR Horton (DHI)	2000-2004	736.59%
East West Bancorp (EWBC)	2000-2004	693.15%
Cameco (CCJ)	2000-2004	662.16%
Insmed (INSM)	2000-2004	641.79%
Toll Brothers (TOL)	2000-2004	636.75%
Old Dominion Freight Line (ODFL)	2000-2004	628.33%
UnitedHealth (UNH)	2000-2004	564.33%
JB Hunt Transport Services (JBHT)	2000-2004	533.56%
Quest Diagnostics (DGX)	2000-2004	524.78%
Ambev SA ADR (ABEV)	2000-2004	520.17%
CACI International (CACI)	2000-2004	502.25%

Large-cap stocks are treated as having a market cap of $10B+.