Monster Beverage (MNST) had the highest return between 2005 and 2005 by a large-cap US stock, returning 321.5%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2005-2005	321.54%
Banco Bradesco SA ADR (BBD)	2005-2005	293.16%
Nasdaq (NDAQ)	2005-2005	235.05%
Sterling Construction (STRL)	2005-2005	223.65%
Intuitive Surgical (ISRG)	2005-2005	193.03%
Suzano Papel e Celulose SA ADR (SUZ)	2005-2005	188.89%
Hologic (HOLX)	2005-2005	169.51%
Vertex Pharmaceuticals (VRTX)	2005-2005	158.6%
Tenaris SA ADR (TS)	2005-2005	141.95%
Woori Financial (WF)	2005-2005	140.33%
Canadian Natural Resources (CNQ)	2005-2005	133.26%
Valero Energy (VLO)	2005-2005	127.92%
Apple (AAPL)	2005-2005	121.96%
Netflix (NFLX)	2005-2005	116.83%
Grupo Cibest (CIB)	2005-2005	111.91%
Alphabet Inc Class A (GOOGL)	2005-2005	110.16%
EOG Resources (EOG)	2005-2005	106.25%
Wheaton Precious Metals (WPM)	2005-2005	96.61%
Royal Gold (RGLD)	2005-2005	96.02%
Salesforce (CRM)	2005-2005	95.31%
Clean Harbors (CLH)	2005-2005	89.54%
Woodside Energy (WDS)	2005-2005	88.48%
Orix Corp Ads (IX)	2005-2005	87.27%
KB Financial (KB)	2005-2005	87.19%
Alamos Gold (AGI)	2005-2005	84%

Large-cap stocks are treated as having a market cap of $10B+.