Expedia (EXPE) had the highest return between 2005 and 2005 by a large-cap US stock, returning 5,827.7%.

ASSET	YEARS	% RETURN
Expedia (EXPE)	2005-2005	5,827.71%
Paramount Skydance Corporation Class B Common Stock (PSKY)	2005-2005	1,014.74%
Monster Beverage (MNST)	2005-2005	321.54%
Nasdaq (NDAQ)	2005-2005	235.04%
Sterling Construction (STRL)	2005-2005	223.65%
Banco Bradesco SA ADR (BBD)	2005-2005	216.49%
Intuitive Surgical (ISRG)	2005-2005	193.03%
Hudbay Minerals (HBM)	2005-2005	190.47%
Suzano Papel e Celulose SA ADR (SUZ)	2005-2005	188.89%
Vertex Pharmaceuticals (VRTX)	2005-2005	158.6%
Gildan Activewear (GIL)	2005-2005	152.06%
Tenaris SA ADR (TS)	2005-2005	141.95%
Woori Financial (WF)	2005-2005	140.33%
QXO (QXO)	2005-2005	133.33%
Canadian Natural Resources (CNQ)	2005-2005	133.26%
Valero Energy (VLO)	2005-2005	127.97%
Apple (AAPL)	2005-2005	121.96%
Netflix (NFLX)	2005-2005	116.83%
HF Sinclair (DINO)	2005-2005	112.5%
Grupo Cibest (CIB)	2005-2005	111.91%
Alphabet Inc Class A (GOOGL)	2005-2005	110.17%
EOG Resources (EOG)	2005-2005	106.25%
Wheaton Precious Metals (WPM)	2005-2005	96.61%
Royal Gold (RGLD)	2005-2005	96.02%
Salesforce (CRM)	2005-2005	95.31%

Large-cap stocks are treated as having a market cap of $10B+.