Jazz Pharmaceuticals (JAZZ) had the highest return between 2010 and 2011 by a large-cap US stock, returning 379.3%.

ASSET	YEARS	% RETURN
Jazz Pharmaceuticals (JAZZ)	2010-2011	379.28%
Domino's Pizza Inc Common Stock (DPZ)	2010-2011	298.01%
Chipotle Mexican Grill (CMG)	2010-2011	276.94%
Cheniere Energy (LNG)	2010-2011	247.6%
Ulta Beauty (ULTA)	2010-2011	237.6%
Neurocrine Biosciences (NBIX)	2010-2011	206.86%
Lululemon Athletica (LULU)	2010-2011	202.3%
United Rentals (URI)	2010-2011	197.88%
Baidu (BIDU)	2010-2011	179.99%
Las Vegas Sands (LVS)	2010-2011	173.91%
Tractor Supply (TSCO)	2010-2011	167.78%
Dycom Industries (DY)	2010-2011	157.32%
Dollar Tree (DLTR)	2010-2011	156.88%
Fortinet (FTNT)	2010-2011	143.96%
Dillard's (DDS)	2010-2011	141.83%
Monster Beverage (MNST)	2010-2011	138.33%
XPO Logistics (XPO)	2010-2011	137.45%
Estee Lauder Companies (EL)	2010-2011	135.22%
Regeneron Pharmaceuticals (REGN)	2010-2011	128.67%
Ross Stores (ROST)	2010-2011	127.51%
Deckers Outdoor (DECK)	2010-2011	120.11%
Somnigroup International (SGI)	2010-2011	118.97%
Lattice Semiconductor (LSCC)	2010-2011	117.58%
Fastenal (FAST)	2010-2011	117.27%
Generac (GNRC)	2010-2011	115.62%

Large-cap stocks are treated as having a market cap of $10B+.