Celestica (CLS) has had the highest return between 2021 and 2025 by a large-cap US stock, returning 3,292.1%.

ASSET	YEARS	% RETURN
Celestica (CLS)	2021-2025	3,292.15%
Sterling Construction (STRL)	2021-2025	1,803.53%
Super Micro Computer (SMCI)	2021-2025	1,540.88%
Oklo (OKLO)	2021-2025	1,533.9%
Comfort Systems USA (FIX)	2021-2025	1,506.09%
NVIDIA (NVDA)	2021-2025	1,301.92%
Credo Technology (CRDO)	2021-2025	1,086.86%
Vistra Energy (VST)	2021-2025	1,038.3%
Constellation Energy (CEG)	2021-2025	950.67%
Fortress Transp & Infra Inv (FTAI)	2021-2025	891.07%
Vertiv (VRT)	2021-2025	831.17%
Permian Resources (PR)	2021-2025	819.43%
Broadcom (AVGO)	2021-2025	782.12%
Carpenter Technology (CRS)	2021-2025	770.38%
Embraer SA ADR (ERJ)	2021-2025	762.75%
Applovin (APP)	2021-2025	756.16%
Arista Networks (ANET)	2021-2025	687.45%
EMCOR (EME)	2021-2025	661.08%
Flex (FLEX)	2021-2025	650.32%
Palantir Technologies Inc Class A Common Stock (PLTR)	2021-2025	645.09%
Coca-Cola Consolidated (COKE)	2021-2025	610.28%
MicroStrategy (MSTR)	2021-2025	596.25%
Mr Cooper (COOP)	2021-2025	576.4%
Howmet Aerospace (HWM)	2021-2025	574.49%
Symbotic (SYM)	2021-2025	559.48%

Large-cap stocks are treated as having a market cap of $10B+.