Ferguson (FERG) had the highest return between 2008 and 2012 by a large-cap US stock, returning 38,968.2%.

ASSET	YEARS	% RETURN
Ferguson (FERG)	2008-2012	38,968.16%
Regeneron Pharmaceuticals (REGN)	2008-2012	612.2%
Ulta Beauty (ULTA)	2008-2012	484.47%
Booking (BKNG)	2008-2012	431.38%
Tractor Supply (TSCO)	2008-2012	406.8%
Dollar Tree (DLTR)	2008-2012	369.44%
Westlake Chemical (WLK)	2008-2012	359.39%
Ross Stores (ROST)	2008-2012	349.07%
XPO Logistics (XPO)	2008-2012	295.03%
Edwards Lifesciences (EW)	2008-2012	294.44%
Franco-Nevada (FNV)	2008-2012	292.2%
Transdigm (TDG)	2008-2012	291.1%
Tyler Technologies (TYL)	2008-2012	277.26%
Ambev SA ADR (ABEV)	2008-2012	274.49%
Domino's Pizza Inc Common Stock (DPZ)	2008-2012	255.95%
Netflix (NFLX)	2008-2012	248.6%
F5 Networks (FFIV)	2008-2012	246.72%
Old Dominion Freight Line (ODFL)	2008-2012	239.77%
LyondellBasell Industries (LYB)	2008-2012	231.8%
Coca-Cola Femsa SAB de CV ADR (KOF)	2008-2012	230.87%
EXACT Sciences (EXAS)	2008-2012	225.85%
Ecopetrol SA ADR (EC)	2008-2012	222.21%
Lululemon Athletica (LULU)	2008-2012	221.71%
TJX Companies (TJX)	2008-2012	216.36%
Banco De Chile (BCH)	2008-2012	204.03%

Large-cap stocks are treated as having a market cap of $10B+.