Inventrust Properties (IVT) had the highest return between 2013 and 2015 by a US stock with a market cap of $1B+, returning 751,855%.

ASSET	YEARS	% RETURN
Inventrust Properties (IVT)	2013-2015	751,855%
Cidara Therapeutics (CDTX)	2013-2015	2,045%
CleanSpark (CLSK)	2013-2015	1,053.86%
Genmab A-S (GMAB)	2013-2015	857.29%
Vipshop (VIPS)	2013-2015	748.78%
Netflix (NFLX)	2013-2015	740.94%
ACADIA Pharmaceuticals (ACAD)	2013-2015	645.82%
Neurocrine Biosciences (NBIX)	2013-2015	636.59%
Celsius (CELH)	2013-2015	593.14%
Tesla (TSLA)	2013-2015	585.75%
BioCryst Pharmaceuticals (BCRX)	2013-2015	549.06%
Incyte (INCY)	2013-2015	548.62%
ANI Pharmaceuticals (ANIP)	2013-2015	501.67%
Pampa Energia SA ADR (PAM)	2013-2015	490.52%
DexCom (DXCM)	2013-2015	489.63%
Applied Digital (APLD)	2013-2015	486.21%
Ionis Pharmaceuticals (IONS)	2013-2015	482.6%
Travere Therapeutics (TVTX)	2013-2015	467.35%
Catalyst Pharmaceuticals (CPRX)	2013-2015	463.22%
Nexstar Broadcasting (NXST)	2013-2015	463.13%
Ligand Pharmaceuticals (LGND)	2013-2015	409.49%
Alnylam Pharmaceuticals (ALNY)	2013-2015	396.78%
TAL Education (TAL)	2013-2015	379.08%
Broadcom (AVGO)	2013-2015	370.19%
Ambarella (AMBA)	2013-2015	365.28%