NVIDIA (NVDA) has had the highest return between 2020 and 2025 by a mega-cap US stock, returning 3,243.5%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2020-2025	3,243.54%
Palantir Technologies Inc Class A Common Stock (PLTR)	2020-2025	1,807.4%
Tesla (TSLA)	2020-2025	1,469.82%
Broadcom (AVGO)	2020-2025	1,178.57%
Applovin (APP)	2020-2025	769.54%
Eli Lilly and (LLY)	2020-2025	638.52%
GE Aerospace (GE)	2020-2025	458.16%
Taiwan Semiconductor Manufacturing (TSM)	2020-2025	449.33%
Advanced Micro Devices (AMD)	2020-2025	433.61%
Oracle (ORCL)	2020-2025	408.34%
Caterpillar (CAT)	2020-2025	316.41%
Alphabet Inc Class A (GOOGL)	2020-2025	314.49%
Micron Technology (MU)	2020-2025	307.24%
Goldman Sachs (GS)	2020-2025	292.88%
Morgan Stanley (MS)	2020-2025	287.05%
Apple (AAPL)	2020-2025	277.44%
ASML Holding NV ADR (ASML)	2020-2025	260.91%
Costco Wholesale (COST)	2020-2025	249.92%
Microsoft (MSFT)	2020-2025	240.52%
Netflix (NFLX)	2020-2025	235.16%
American Express (AXP)	2020-2025	212.02%
AbbVie (ABBV)	2020-2025	210.84%
Facebook (META)	2020-2025	205.29%
International Business Machines (IBM)	2020-2025	200.09%
Walmart (WMT)	2020-2025	180.32%

Mega-cap stocks are treated as having a market cap of $200B+.