NVIDIA (NVDA) had the highest return between 2019 and 2023 by a mega-cap US stock, returning 1,428.1%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2019-2023	1,428.15%
Tesla (TSLA)	2019-2023	1,117.64%
Advanced Micro Devices (AMD)	2019-2023	718.49%
KLA (KLAC)	2019-2023	618.62%
Lam Research (LRCX)	2019-2023	531.28%
Eli Lilly and (LLY)	2019-2023	450.33%
Applied Materials (AMAT)	2019-2023	435.56%
Broadcom (AVGO)	2019-2023	429.39%
Apple (AAPL)	2019-2023	418.02%
ASML Holding NV ADR (ASML)	2019-2023	417.06%
Novo Nordisk A-S (NVO)	2019-2023	392.32%
Palo Alto Networks (PANW)	2019-2023	378.08%
Microsoft (MSFT)	2019-2023	297.79%
Marvell Technology (MRVL)	2019-2023	290.84%
Costco Wholesale (COST)	2019-2023	259.64%
Dell Technologies (DELL)	2019-2023	230.29%
Taiwan Semiconductor Manufacturing (TSM)	2019-2023	226.95%
GE Aerospace (GE)	2019-2023	190.53%
LIN TV (LIN)	2019-2023	189.6%
Seagate Technology (STX)	2019-2023	180.08%
Micron Technology (MU)	2019-2023	180.03%
Morgan Stanley (MS)	2019-2023	178.89%
Facebook (META)	2019-2023	174.41%
Alphabet Inc Class A (GOOGL)	2019-2023	171.98%
Caterpillar (CAT)	2019-2023	169.27%

Mega-cap stocks are treated as having a market cap of $200B+.