Palantir Technologies (PLTR) had the highest return between 2022 and 2025 by a mega-cap US stock, returning 868.1%.

ASSET	YEARS	% RETURN
Palantir Technologies (PLTR)	2022-2025	868.14%
YPF Sociedad Anonima (YPF)	2022-2025	839.22%
NVIDIA (NVDA)	2022-2025	526.74%
GE Vernova LLC (GEV)	2022-2025	469.67%
Broadcom (AVGO)	2022-2025	460.69%
GE Aerospace (GE)	2022-2025	429.5%
Banco Santander SA ADR (SAN)	2022-2025	312.26%
Eli Lilly and (LLY)	2022-2025	306.48%
Arista Networks (ANET)	2022-2025	263.74%
Mitsubishi UFJ Financial Group Inc ADR (MUFG)	2022-2025	232.5%
HSBC Holdings PLC ADR (HSBC)	2022-2025	228.98%
Amphenol (APH)	2022-2025	219.54%
Micron Technology (MU)	2022-2025	210.72%
Caterpillar (CAT)	2022-2025	197.7%
KLA (KLAC)	2022-2025	194.06%
Taiwan Semiconductor Manufacturing (TSM)	2022-2025	160.97%
International Business Machines (IBM)	2022-2025	158.73%
Goldman Sachs (GS)	2022-2025	150.08%
Lam Research (LRCX)	2022-2025	148.43%
Walmart (WMT)	2022-2025	144.54%
Dell Technologies (DELL)	2022-2025	144.51%
American Express (AXP)	2022-2025	136.45%
Oracle (ORCL)	2022-2025	135.69%
RTX (RTX)	2022-2025	133.3%
Crowdstrike (CRWD)	2022-2025	128.66%

Mega-cap stocks are treated as having a market cap of $200B+.