Applovin (APP) has had the highest return between 2023 and 2025 by a mega-cap US stock, returning 5,310.4%.

ASSET	YEARS	% RETURN
Applovin (APP)	2023-2025	5,310.36%
Palantir Technologies Inc Class A Common Stock (PLTR)	2023-2025	2,698.94%
NVIDIA (NVDA)	2023-2025	1,206.19%
Broadcom (AVGO)	2023-2025	556.32%
GE Aerospace (GE)	2023-2025	498.53%
Facebook (META)	2023-2025	398.91%
Micron Technology (MU)	2023-2025	391.22%
Taiwan Semiconductor Manufacturing (TSM)	2023-2025	300.37%
Advanced Micro Devices (AMD)	2023-2025	292.27%
Netflix (NFLX)	2023-2025	288.34%
Lam Research (LRCX)	2023-2025	286.97%
Tesla (TSLA)	2023-2025	263.47%
Alphabet Inc Class A (GOOGL)	2023-2025	222.25%
Amazon (AMZN)	2023-2025	185.75%
Oracle (ORCL)	2023-2025	185.72%
Eli Lilly and (LLY)	2023-2025	184.15%
HSBC Holdings PLC ADR (HSBC)	2023-2025	182.47%
Goldman Sachs (GS)	2023-2025	160.54%
American Express (AXP)	2023-2025	158.75%
JPMorgan Chase (JPM)	2023-2025	155.1%
SAP SE ADR (SAP)	2023-2025	152.92%
Caterpillar (CAT)	2023-2025	150.63%
International Business Machines (IBM)	2023-2025	149.06%
Walmart (WMT)	2023-2025	125.34%
Wells Fargo (WFC)	2023-2025	124.21%

Mega-cap stocks are treated as having a market cap of $200B+.