Applovin (APP) has had the highest return between 2024 and 2025 by a mega-cap US stock, returning 1,517.2%.

ASSET	YEARS	% RETURN
Applovin (APP)	2024-2025	1,517.18%
Palantir Technologies Inc Class A Common Stock (PLTR)	2024-2025	1,082.71%
NVIDIA (NVDA)	2024-2025	311.37%
Broadcom (AVGO)	2024-2025	245.45%
GE Aerospace (GE)	2024-2025	208.2%
Taiwan Semiconductor Manufacturing (TSM)	2024-2025	201.18%
Arista Networks (ANET)	2024-2025	169.56%
Micron Technology (MU)	2024-2025	168.3%
Oracle (ORCL)	2024-2025	156.89%
Netflix (NFLX)	2024-2025	131.56%
Alibaba (BABA)	2024-2025	127.81%
Raytheon Technologies (RTX)	2024-2025	120.54%
Goldman Sachs (GS)	2024-2025	114.34%
Lam Research (LRCX)	2024-2025	108.46%
Alphabet Inc Class A (GOOGL)	2024-2025	104.35%
Caterpillar (CAT)	2024-2025	102.93%
International Business Machines (IBM)	2024-2025	99.57%
American Express (AXP)	2024-2025	97.86%
HSBC Holdings PLC ADR (HSBC)	2024-2025	97.15%
Walmart (WMT)	2024-2025	96.81%
JPMorgan Chase (JPM)	2024-2025	92.38%
Morgan Stanley (MS)	2024-2025	88.57%
Facebook (META)	2024-2025	85.68%
Wells Fargo (WFC)	2024-2025	84.98%
Tesla (TSLA)	2024-2025	82.57%

Mega-cap stocks are treated as having a market cap of $200B+.