Check-Cap (CHEK) has had the highest return this year by a micro-cap US stock, returning 18,353.6%.

ASSET	YEAR	% RETURN
Check-Cap (CHEK)	2025	18,353.61%
Maywood Acquisition Corp Class A Ordinary Shares (MAYA)	2025	2,415.21%
Oncology Institute (TOI)	2025	955.56%
Abits (ABTS)	2025	886.68%
FiEE (FIEE)	2025	766.97%
Lizhi (SOGP)	2025	677.39%
Global Interactive Technologies (GITS)	2025	431.12%
Above Food Ingredients Inc Common Stock (ABVE)	2025	407.27%
ImmunoPrecise Antibodies (HYFT)	2025	404.88%
JFB Construction Holdings Class A Common Stock (JFB)	2025	387.53%
Galecto (GLTO)	2025	378.87%
Dominari (DOMH)	2025	361.81%
Roman DBDR Acquisition Corp II Warrants (DRDBW)	2025	360%
Resolute Holdings Management (RHLD)	2025	353.22%
Precipio (PRPO)	2025	349.09%
Rapid Micro Biosystems (RPID)	2025	342.86%
ABVC BioPharma (ABVC)	2025	328.81%
Phoenix Asia Holdings Limited Ordinary Shares (PHOE)	2025	328.5%
Sol Gel Technologies (SLGL)	2025	328.42%
Empro Group Inc Ordinary shares (EMPG)	2025	307.51%
Nephros (NEPH)	2025	288.26%
CervoMed (CRVO)	2025	277.5%
American Resources Corp Class A (AREC)	2025	252.22%
Blackboxstocks (BLBX)	2025	247.7%
Vista Gold (VGZ)	2025	245.2%

Micro-cap stocks are treated as having a market cap of <= $300M.