Everbright Digital Holding Limited Ordinary Shares (EDHL) had the highest return last year by a micro-cap US stock, returning 599,900%.

ASSET	YEAR	% RETURN
Everbright Digital Holding Limited Ordinary Shares (EDHL)	2025	599,900%
Propanc Biopharma, Inc Common Stock (PPCB)	2025	89,333.33%
Mint Incorporation Limited Class A Ordinary Shares (MIMI)	2025	74,900%
Splash Beverage (SBEV)	2025	14,266.67%
Profusa, Inc Common Stock (PFSA)	2025	1,550.25%
FiEE (FIEE)	2025	1,372.48%
Zepp Health (ZEPP)	2025	936.15%
Titan Mining (TII)	2025	826.45%
Pulsenmore Ltd Ordinary Shares (PLSM)	2025	703.15%
Diginex Limited Ordinary Shares (DGNX)	2025	683.1%
DeFi Development (DFDV)	2025	650.48%
Newegg Commerce (NEGG)	2025	534.5%
Rich Sparkle Holdings Limited Ordinary Shares (ANPA)	2025	515.33%
Sound (SOGP)	2025	504.25%
Aimei Health Technology Co, Ltd Ordinary Share (AFJK)	2025	501.03%
Anbio Biotechnology Class A Ordinary Shares (NNNN)	2025	471.67%
Dominari (DOMH)	2025	445.63%
Eva Live Inc Common Stock (GOAI)	2025	435.71%
Invivyd (IVVD)	2025	425.53%
WeShop Holdings Limited Class A Ordinary Shares (WSHP)	2025	374.53%
NovaBridge Biosciences (NBP)	2025	368.24%
Pelthos Therapeutics (PTHS)	2025	362.69%
ImmunoPrecise Antibodies (HYFT)	2025	343.9%
Sol Gel Technologies (SLGL)	2025	343.58%
9F (JFU)	2025	326%

Micro-cap stocks are treated as having a market cap of <= $300M.