Applied Digital (APLD) has had the highest return between 2020 and 2025 by a mid-cap US stock, returning 455,038.9%.

ASSET	YEARS	% RETURN
Applied Digital (APLD)	2020-2025	455,038.89%
Regencell Bioscience (RGC)	2020-2025	5,156.49%
QMMM Holdings Limited Ordinary Shares (QMMM)	2020-2025	3,880%
Centrus Energy (LEU)	2020-2025	3,747.24%
Sterling Construction (STRL)	2020-2025	2,172.79%
Alpha Metallurgical Resources (AMR)	2020-2025	1,991.12%
Modine Manufacturing (MOD)	2020-2025	1,858.39%
Sezzle (SEZL)	2020-2025	1,736.03%
IES (IESC)	2020-2025	1,645.96%
Uranium Energy (UEC)	2020-2025	1,401.08%
Sitime (SITM)	2020-2025	1,309.58%
Riot Blockchain (RIOT)	2020-2025	1,260.53%
Cogent Biosciences (COGT)	2020-2025	1,201.69%
Indivior PLC Ordinary Shares (INDV)	2020-2025	1,176.95%
Protagonist Therapeutics (PTGX)	2020-2025	1,149.08%
Belite Bio Inc ADR (BLTE)	2020-2025	1,093.04%
Hut 8 Corp Common Stock (HUT)	2020-2025	1,018.56%
Skeena Resources (SKE)	2020-2025	999.25%
Camtek (CAMT)	2020-2025	976.97%
Abivax SA American Depositary Shares (ABVX)	2020-2025	960.69%
Argan (AGX)	2020-2025	877.66%
Bel Fuse A (BELFA)	2020-2025	866.1%
Freedom (FRHC)	2020-2025	801.49%
Celcuity LLC (CELC)	2020-2025	797.9%
Nova (NVMI)	2020-2025	778.5%

Mid-cap stocks are treated as having a market cap between $2B and $10B.