Applied Digital (APLD) had the highest return between 2019 and 2022 by a mid-cap US stock, returning 16,476.6%.

ASSET	YEARS	% RETURN
Applied Digital (APLD)	2019-2022	16,476.58%
Weatherford International (WFRD)	2019-2022	9,491.02%
Enphase Energy (ENPH)	2019-2022	5,622.68%
Teekay Tankers (TNK)	2019-2022	3,168.33%
Axsome Therapeutics (AXSM)	2019-2022	2,644.84%
Centrus Energy (LEU)	2019-2022	1,880.49%
Moderna (MRNA)	2019-2022	1,103.08%
Plug Power (PLUG)	2019-2022	897.58%
Catalyst Pharmaceuticals (CPRX)	2019-2022	878.95%
Lattice Semiconductor (LSCC)	2019-2022	845.77%
Daqo New Energy Corp ADR (DQ)	2019-2022	738.98%
SolarEdge Technologies (SEDG)	2019-2022	723.22%
Sitime (SITM)	2019-2022	681.69%
Impinj (PI)	2019-2022	666.18%
Avis Budget (CAR)	2019-2022	642.1%
Cytokinetics (CYTK)	2019-2022	636.66%
Freedom (FRHC)	2019-2022	623.23%
Calix (CALX)	2019-2022	612.81%
Chord Energy (CHRD)	2019-2022	561.33%
ELF Beauty (ELF)	2019-2022	548.3%
GameStop (GME)	2019-2022	513.21%
Xenon Pharmaceuticals (XENE)	2019-2022	508.49%
Torm PLC Class A (TRMD)	2019-2022	505.6%
Inspire Medical Systems (INSP)	2019-2022	505.34%
Skeena Resources (SKE)	2019-2022	504.55%

Mid-cap stocks are treated as having a market cap between $2B and $10B.