Perpetua Resources (PPTA) had the highest return between 2021 and 2024 by a mid-cap US stock, returning 11,131.6%.

ASSET	YEARS	% RETURN
Perpetua Resources (PPTA)	2021-2024	11,131.58%
Applied Digital (APLD)	2021-2024	3,295.56%
Vista Energy, SAB de CV (VIST)	2021-2024	1,989.19%
Alpha Metallurgical Resources (AMR)	2021-2024	1,757.33%
Weatherford International (WFRD)	2021-2024	1,113.42%
Sezzle (SEZL)	2021-2024	1,029.36%
Modine Manufacturing (MOD)	2021-2024	818.62%
Grupo Financiero Galicia SA ADR (GGAL)	2021-2024	783.71%
Enlight Renewable Energy Ltd Ordinary Shares (ENLT)	2021-2024	780.61%
Peabody Energy (BTU)	2021-2024	770.63%
ADMA Biologics (ADMA)	2021-2024	749.01%
Alliance Resource Partners (ARLP)	2021-2024	739.22%
Powell Industries (POWL)	2021-2024	721.27%
BBVA Banco Frances SA ADR (BBAR)	2021-2024	708.98%
Banco Macro SA B ADR (BMA)	2021-2024	706.95%
Innodata (INOD)	2021-2024	638.69%
Abercrombie & Fitch (ANF)	2021-2024	628.77%
Calumet Specialty Products Partners (CLMT)	2021-2024	608.04%
Viking Therapeutics (VKTX)	2021-2024	605.96%
Bel Fuse A (BELFA)	2021-2024	591.41%
Aehr Test Systems (AEHR)	2021-2024	565.2%
Lantheus (LNTH)	2021-2024	562.18%
SM Energy (SM)	2021-2024	553.41%
Pampa Energia SA ADR (PAM)	2021-2024	539.56%
Sprouts Farmers Market LLC (SFM)	2021-2024	529.06%

Mid-cap stocks are treated as having a market cap between $2B and $10B.