Weatherford International (WFRD) had the highest return between 2018 and 2022 by a mid-cap US stock, returning 1,921,376.9%.

ASSET	YEARS	% RETURN
Weatherford International (WFRD)	2018-2022	1,921,376.92%
Applied Digital (APLD)	2018-2022	30,566.67%
Enphase Energy (ENPH)	2018-2022	10,986.19%
Xenon Pharmaceuticals (XENE)	2018-2022	1,308.21%
Axsome Therapeutics (AXSM)	2018-2022	1,265.13%
Calix (CALX)	2018-2022	1,059.83%
Lattice Semiconductor (LSCC)	2018-2022	1,022.49%
Arrowhead Pharmaceuticals (ARWR)	2018-2022	999.19%
Inspire Medical Systems (INSP)	2018-2022	928.5%
Crocs (CROX)	2018-2022	757.83%
Centrus Energy (LEU)	2018-2022	718.14%
Krystal Biotech (KRYS)	2018-2022	692.2%
Sitime (SITM)	2018-2022	681.69%
Freedom (FRHC)	2018-2022	675.23%
SolarEdge Technologies (SEDG)	2018-2022	652.38%
Ameresco (AMRC)	2018-2022	564.42%
Chord Energy (CHRD)	2018-2022	561.33%
Agilysys (AGYS)	2018-2022	541.33%
Trump Media & Technology (DJTWW)	2018-2022	523.01%
Dillard's (DDS)	2018-2022	505.95%
Kinsale Capital (KNSL)	2018-2022	487.86%
Etsy (ETSY)	2018-2022	484.29%
Magnite (MGNI)	2018-2022	466.31%
Cytokinetics (CYTK)	2018-2022	462.21%
SPS Commerce (SPSC)	2018-2022	427.54%

Mid-cap stocks are treated as having a market cap between $2B and $10B.