SharonAI Holdings, Inc Class A Common Stock (SHAZ) had the highest return in Q4 2025 by a mid-cap US stock, returning 186,391.9%.

ASSET	QUARTER	% RETURN
SharonAI Holdings, Inc Class A Common Stock (SHAZ)	Q4 2025	186,391.94%
Hycroft Mining (HYMC)	Q4 2025	277.9%
AXT (AXTI)	Q4 2025	264.14%
PACS (PACS)	Q4 2025	183.32%
Cogent Biosciences (COGT)	Q4 2025	151.91%
Structure Therapeutics Inc American Depositary Shares (GPCR)	Q4 2025	148.57%
Alumis (ALMS)	Q4 2025	146.46%
Nuvation Bio (NUVB)	Q4 2025	139.89%
Sellas Life Sciences (SLS)	Q4 2025	131.29%
Vicor (VICR)	Q4 2025	123.13%
Central Puerto (CEPU)	Q4 2025	116.58%
Belite Bio Inc ADR (BLTE)	Q4 2025	116.58%
BBVA Banco Frances SA ADR (BBAR)	Q4 2025	111.94%
Banco Macro SA B ADR (BMA)	Q4 2025	110.33%
Nurix Therapeutics (NRIX)	Q4 2025	104.86%
Celcuity LLC (CELC)	Q4 2025	103.22%
Butterfly Network (BFLY)	Q4 2025	96.89%
Grupo Financiero Galicia SA ADR (GGAL)	Q4 2025	96.76%
Spyre Therapeutics (SYRE)	Q4 2025	95.82%
Immunome (IMNM)	Q4 2025	87.11%
Axogen (AXGN)	Q4 2025	84.19%
Fluence Energy (FLNC)	Q4 2025	79.82%
Establishment Labs (ESTA)	Q4 2025	77.84%
Arcus Biosciences (RCUS)	Q4 2025	77.57%
Kodiak Sciences (KOD)	Q4 2025	76.74%

Mid-cap stocks are treated as having a market cap between $2B and $10B.