Regencell Bioscience (RGC) has had the highest return this year by a US stock in the Nasdaq Composite (IXIC), returning 11,891%.

ASSET	YEAR	% RETURN
Regencell Bioscience (RGC)	2025	11,891.02%
QMMM Holdings Limited Ordinary Shares (QMMM)	2025	9,155.81%
Diginex Limited Ordinary Shares (DGNX)	2025	2,589.2%
WW International, Inc Common Stock (WW)	2025	2,217.56%
DeFi Development (DFDV)	2025	2,062.28%
Oncology Institute (TOI)	2025	1,406.54%
Abivax SA American Depositary Shares (ABVX)	2025	1,149.59%
Abits (ABTS)	2025	1,091.22%
FiEE (FIEE)	2025	1,033.03%
Lizhi (SOGP)	2025	847.43%
Better Home & Finance (BETR)	2025	840.14%
180 Life Sciences (ATNF)	2025	838.55%
Above Food Ingredients Inc Common Stock (ABVE)	2025	829.09%
Nova Lifestyle I (NVFY)	2025	771.41%
Global Interactive Technologies (GITS)	2025	729.88%
Rich Sparkle Holdings Limited Ordinary Shares (ANPA)	2025	591.67%
Dominari (DOMH)	2025	560.2%
TMC the metals (TMC)	2025	527.19%
Nanobiotix (NBTX)	2025	519.94%
Palvella Therapeutics (PVLA)	2025	514.13%
ThredUp (TDUP)	2025	513.19%
Newegg Commerce (NEGG)	2025	492.13%
Phoenix Asia Holdings Limited Ordinary Shares (PHOE)	2025	451%
IREN (IREN)	2025	441.8%
Celcuity LLC (CELC)	2025	433.81%