NVIDIA (NVDA) has had the highest return between 2018 and 2025 by a US stock in the S&P 500 (GSPC), returning 3,855.7%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2018-2025	3,855.67%
Axon Enterprise (AXON)	2018-2025	2,724.28%
Advanced Micro Devices (AMD)	2018-2025	2,392.03%
Super Micro Computer (SMCI)	2018-2025	2,367.46%
Tesla (TSLA)	2018-2025	2,075.1%
Palantir Technologies Inc Class A Common Stock (PLTR)	2018-2025	1,791.8%
Broadcom (AVGO)	2018-2025	1,633.23%
KLA-Tencor (KLAC)	2018-2025	1,197.58%
Vistra Energy (VST)	2018-2025	1,174.1%
Trade Desk (TTD)	2018-2025	1,073.34%
Quanta Services (PWR)	2018-2025	1,046.1%
Eli Lilly and (LLY)	2018-2025	1,000.64%
Fair Isaac (FICO)	2018-2025	998.42%
Arista Networks (ANET)	2018-2025	965.01%
Constellation Energy (CEG)	2018-2025	963.31%
Monolithic Power Systems (MPWR)	2018-2025	942.29%
Howmet Aerospace (HWM)	2018-2025	893.65%
Fortinet (FTNT)	2018-2025	874.52%
EMCOR (EME)	2018-2025	848.89%
Lam Research (LRCX)	2018-2025	848.03%
Applovin (APP)	2018-2025	818.71%
Palo Alto Networks (PANW)	2018-2025	805.3%
Williams-Sonoma (WSM)	2018-2025	786.93%
Jabil Circuit (JBL)	2018-2025	738.6%
Cadence Design Systems (CDNS)	2018-2025	736.67%