NVIDIA (NVDA) has had the highest return between 2020 and 2025 by a US stock in the S&P 500 (GSPC), returning 2,948.3%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2020-2025	2,948.29%
Super Micro Computer (SMCI)	2020-2025	2,198.53%
Palantir Technologies Inc Class A Common Stock (PLTR)	2020-2025	1,715.1%
Tesla (TSLA)	2020-2025	1,463.96%
Broadcom (AVGO)	2020-2025	1,144.86%
Arista Networks (ANET)	2020-2025	1,035.28%
Quanta Services (PWR)	2020-2025	979.36%
Crowdstrike (CRWD)	2020-2025	907.3%
Constellation Energy (CEG)	2020-2025	875.34%
Axon Enterprise (AXON)	2020-2025	855.2%
Vistra Energy (VST)	2020-2025	824.73%
Howmet Aerospace (HWM)	2020-2025	743.27%
EMCOR (EME)	2020-2025	709.7%
Applovin (APP)	2020-2025	689.49%
KLA-Tencor (KLAC)	2020-2025	580.92%
Eli Lilly and (LLY)	2020-2025	551.14%
Dell Technologies (DELL)	2020-2025	517.98%
United Rentals (URI)	2020-2025	513.22%
Monolithic Power Systems (MPWR)	2020-2025	496.25%
McKesson (MCK)	2020-2025	488.64%
Williams-Sonoma (WSM)	2020-2025	485.38%
Interactive Brokers (IBKR)	2020-2025	481.73%
Oracle (ORCL)	2020-2025	463.6%
GE Aerospace (GE)	2020-2025	462.62%
Palo Alto Networks (PANW)	2020-2025	451.54%