Seaport Therapeutics, Inc Common Stock (SPTX) has had the highest return this year by a small-cap US stock, returning 166,700%.

ASSET	YEAR	% RETURN
Seaport Therapeutics, Inc Common Stock (SPTX)	2026	166,700%
SharonAI Holdings, Inc Class A Common Stock (SHAZ)	2026	1,531.58%
Mega Fortune Company Limited Ordinary Shares (MGRT)	2026	1,331.87%
TJGC (TJGC)	2026	1,081.11%
Adlai Nortye Ltd American Depositary Shares (ANL)	2026	666.2%
BUUU (BUUU)	2026	578.04%
Roma Green Finance Limited Ordinary Shares (ROMA)	2026	423.13%
agilon health (AGL)	2026	398.43%
Korsana Biosciences (KRSA)	2026	292.23%
Anterix (ATEX)	2026	282.1%
Avita Medical (RCEL)	2026	275.36%
Quantum (QMCO)	2026	255.06%
Rackspace Technology (RXT)	2026	220.04%
Eton Pharmaceuticals (ETON)	2026	213.27%
Silicom (SILC)	2026	209.3%
Bandwidth (BAND)	2026	205.22%
Kosmos Energy (KOS)	2026	196.73%
Zhong Yang Financial Group Limited Ordinary Shares (TOP)	2026	196.44%
Paysign (PAYS)	2026	193.8%
RF Acquisition Corp II Ordinary Shares (RFAI)	2026	179.53%
NN (NNBR)	2026	172.44%
First Tracks Biotherapeutics (TRAX)	2026	170.44%
Alpha Tau Medical (DRTS)	2026	170%
Nordic American Tankers (NAT)	2026	165.84%
Turn Therapeutics Inc Common Stock (TTRX)	2026	165.16%

Small-cap stocks are treated as having a market cap between $300M and $2B.