Seaport Therapeutics, Inc Common Stock (SPTX) has had the highest return this year by a small-cap US stock, returning 179,900%.

ASSET	YEAR	% RETURN
Seaport Therapeutics, Inc Common Stock (SPTX)	2026	179,900%
Mega Fortune Company Limited Ordinary Shares (MGRT)	2026	916.62%
Adlai Nortye Ltd American Depositary Shares (ANL)	2026	626.76%
agilon health (AGL)	2026	543.91%
Julong Holding Limited Class A Ordinary Shares (JLHL)	2026	500%
Rackspace Technology (RXT)	2026	453.58%
Roma Green Finance Limited Ordinary Shares (ROMA)	2026	385.31%
Syntec Optics (OPTX)	2026	356.9%
Atomera (ATOM)	2026	296.48%
Hyliion (HYLN)	2026	295.72%
Anterix (ATEX)	2026	278.61%
Swarmer, Inc Common Stock (SWMR)	2026	261.52%
QuickLogic (QUIK)	2026	260.5%
Vishay Precision (VPG)	2026	259.59%
Satellogic V (SATL)	2026	243.3%
Entravision Communications (EVC)	2026	235.24%
Kosmos Energy (KOS)	2026	214.25%
Ambiq Micro (AMBQ)	2026	198.31%
Silvaco Group, Inc Common Stock (SVCO)	2026	196.83%
Lightwave Logic (LWLG)	2026	195.08%
Boost Run Inc Class A Common Stock (BRUN)	2026	190.33%
Cardinal Infrastructure Group Inc Class A Common Stock (CDNL)	2026	186.61%
Climb Bio (CLYM)	2026	179.02%
Airsculpt Technologies (AIRS)	2026	163.55%
Arteris (AIP)	2026	159.99%

Small-cap stocks are treated as having a market cap between $300M and $2B.