Charming Medical Limited Class A Ordinary Shares (MCTA) had the highest return in October 2025 by a small-cap US stock, returning 412%.

ASSET	MONTH	% RETURN
Charming Medical Limited Class A Ordinary Shares (MCTA)	October 2025	411.98%
Alto Neuroscience (ANRO)	October 2025	254.75%
New Era Energy & Digital (NUAI)	October 2025	174.33%
Digi Power X (DGXX)	October 2025	162.17%
Grupo Supervielle (SUPV)	October 2025	150.91%
Inhibrx Biosciences (INBX)	October 2025	143.69%
GSI Technology (GSIT)	October 2025	142.4%
Replimune (REPL)	October 2025	135.02%
Currenc Group Inc Ordinary Shares (CURR)	October 2025	123.67%
Phoenix Asia Holdings Limited Ordinary Shares (PHOE)	October 2025	118.54%
Empresa Distribuidora y Comercializadora Norte SA ADR (EDN)	October 2025	117.43%
Critical Metals Corp Ordinary Shares (CRML)	October 2025	113.88%
Newegg Commerce (NEGG)	October 2025	111.45%
Trilogy Metals (TMQ)	October 2025	106.98%
Galecto (GLTO)	October 2025	101.1%
Damora Therapeutics (DMRA)	October 2025	101.1%
ProPetro (PUMP)	October 2025	99.62%
SEALSQ (LAES)	October 2025	99.46%
Neurogene (NGNE)	October 2025	98.15%
Palisade Bio (PALI)	October 2025	97.14%
Datavault AI (DVLT)	October 2025	89.72%
Syntec Optics (OPTX)	October 2025	88.89%
Pacific Biosciences of California (PACB)	October 2025	85.71%
Solid Power (SLDP)	October 2025	83.63%
Immix Biopharma (IMMX)	October 2025	83.57%

Small-cap stocks are treated as having a market cap between $300M and $2B.