Alto Neuroscience (ANRO) had the highest return in October 2025 by a small-cap US stock, returning 254.8%.

ASSET	MONTH	% RETURN
Alto Neuroscience (ANRO)	October 2025	254.75%
Ventyx Biosciences (VTYX)	October 2025	159.27%
Grupo Supervielle (SUPV)	October 2025	150.91%
Inhibrx Biosciences (INBX)	October 2025	143.69%
Replimune (REPL)	October 2025	135.02%
Empresa Distribuidora y Comercializadora Norte SA ADR (EDN)	October 2025	117.43%
Nova Minerals (NVA)	October 2025	113.94%
Critical Metals Corp Ordinary Shares (CRML)	October 2025	113.88%
Newegg Commerce (NEGG)	October 2025	111.45%
Trilogy Metals (TMQ)	October 2025	106.98%
ProPetro (PUMP)	October 2025	99.62%
SEALSQ (LAES)	October 2025	99.46%
Neurogene (NGNE)	October 2025	98.15%
Pacific Biosciences of California (PACB)	October 2025	85.71%
Solid Power (SLDP)	October 2025	83.63%
Omeros (OMER)	October 2025	78.78%
AXT (AXTI)	October 2025	77.06%
Monte Rosa Therapeutics (GLUE)	October 2025	73.88%
Astria Therapeutics (ATXS)	October 2025	73.01%
Northern Dynasty Minerals (NAK)	October 2025	68.91%
Neumora Therapeutics (NMRA)	October 2025	66.85%
Hotel101 Global Holdings Corp Class A Ordinary Shares (HBNB)	October 2025	66%
AMTD Digital (HKD)	October 2025	62.09%
Bally's (BALY)	October 2025	61.44%
Invivyd (IVVD)	October 2025	58.56%

Small-cap stocks are treated as having a market cap between $300M and $2B.