best performing small cap stocks last 5 years

Seaport Therapeutics, Inc Common Stock (SPTX) has had the highest return between October 13, 2021 and October 13, 2026 by a small-cap US stock, returning 171,400%.

ASSETDATE% RETURN
Seaport Therapeutics, Inc Common Stock (SPTX)
10/13/2021 - 10/13/2026
171,400%
Jade Biosciences (JBIO)
10/13/2021 - 10/13/2026
93,859.73%
Mega Fortune Company Limited Ordinary Shares (MGRT)
10/13/2021 - 10/13/2026
2,456.39%
SharonAI Holdings, Inc Class A Common Stock (SHAZ)
10/13/2021 - 10/13/2026
1,778.42%
Power Solutions International, Inc Common Stock (PSIX)
10/13/2021 - 10/13/2026
1,013.33%
Eton Pharmaceuticals (ETON)
10/13/2021 - 10/13/2026
996.23%
BUUU (BUUU)
10/13/2021 - 10/13/2026
927.13%
Collective Mining Ltd Common Shares (CNL)
10/13/2021 - 10/13/2026
894.19%
Trevi Therapeutics (TRVI)
10/13/2021 - 10/13/2026
872.18%
Teekay (TK)
10/13/2021 - 10/13/2026
812.34%
Frequency Electronics (FEIM)
10/13/2021 - 10/13/2026
809.9%
M-tron Industries (MPTI)
10/13/2021 - 10/13/2026
775%
Inhibrx Biosciences (INBX)
10/13/2021 - 10/13/2026
731.6%
Santacruz Silver Mining Ltd Common Shares (SCZM)
10/13/2021 - 10/13/2026
708.18%
Limbach (LMB)
10/13/2021 - 10/13/2026
685.69%
Tsakos Energy Navigation (TEN)
10/13/2021 - 10/13/2026
627.34%
Permian Basin Royalty Trust (PBT)
10/13/2021 - 10/13/2026
604.59%
Ardmore Shpng (ASC)
10/13/2021 - 10/13/2026
575.21%
Avino Silver & Gold Mines (ASM)
10/13/2021 - 10/13/2026
558.54%
Charming Medical Limited Class A Ordinary Shares (MCTA)
10/13/2021 - 10/13/2026
539.54%
Graham (GHM)
10/13/2021 - 10/13/2026
535.16%
Preformed Line Products (PLPC)
10/13/2021 - 10/13/2026
504.44%
Paysign (PAYS)
10/13/2021 - 10/13/2026
497.24%
NGL Energy Partners (NGL)
10/13/2021 - 10/13/2026
484.46%
Nordic American Tankers (NAT)
10/13/2021 - 10/13/2026
478.29%
Small-cap stocks are treated as having a market cap between $300M and $2B.