MMTEC (MTC) had the highest return in November 2025 by a small-cap US stock, returning 312.1%.

ASSET	MONTH	% RETURN
MMTEC (MTC)	November 2025	312.12%
Olema Pharmaceuticals (OLMA)	November 2025	214.67%
Alto Ingredients (ALTO)	November 2025	155%
Damora Therapeutics (DMRA)	November 2025	146.26%
Relmada Therapeutics (RLMD)	November 2025	103.15%
Falcon's Beyond Global, Inc Class A Common Stock (FBYD)	November 2025	85.81%
Ironwood Pharmaceuticals (IRWD)	November 2025	78.57%
Babcock & Wilcox Enterprises (BW)	November 2025	73.61%
Inspire Medical Systems (INSP)	November 2025	72.65%
Sigma Lithium Resources (SGML)	November 2025	69.44%
Neuropace (NPCE)	November 2025	65.59%
Hotel101 Global Holdings Corp Class A Ordinary Shares (HBNB)	November 2025	63.33%
Tactile Systems Technology (TCMD)	November 2025	61.09%
Rigel Pharmaceuticals (RIGL)	November 2025	59.88%
Herbalife Nutrition (HLF)	November 2025	57.16%
Castle Biosciences (CSTL)	November 2025	56.67%
NGL Energy Partners (NGL)	November 2025	56.03%
Magnera Corp placeholder (MAGN)	November 2025	55.95%
Hycroft Mining (HYMC)	November 2025	53.95%
Compass Therapeutics (CMPX)	November 2025	53.85%
Natures Sunshine Products (NATR)	November 2025	53.24%
Savara (SVRA)	November 2025	51.57%
Enviri (NVRI)	November 2025	50.57%
CeriBell (CBLL)	November 2025	48.99%
Holley (HLLY)	November 2025	48.95%

Small-cap stocks are treated as having a market cap between $300M and $2B.