Expedia (EXPE) had the highest return between 2005 and 2012 by a US stock in the S&P 500 (GSPC), returning 10,539.7%.

ASSET	YEARS	% RETURN
Expedia (EXPE)	2005-2012	10,539.74%
Booking (BKNG)	2005-2012	2,515.47%
Monster Beverage (MNST)	2005-2012	2,161.03%
Paramount Skydance Corporation Class B Common Stock (PSKY)	2005-2012	1,961.64%
Regeneron Pharmaceuticals (REGN)	2005-2012	1,727.67%
Apple (AAPL)	2005-2012	1,557.6%
CF Industries (CF)	2005-2012	1,196.65%
Mastercard (MA)	2005-2012	1,142.49%
Intuitive Surgical (ISRG)	2005-2012	1,125.33%
Salesforce (CRM)	2005-2012	924.36%
Netflix (NFLX)	2005-2012	641.84%
Transdigm (TDG)	2005-2012	637.28%
Contura Energy (CTRA)	2005-2012	592.8%
Chipotle Mexican Grill (CMG)	2005-2012	561.02%
Lululemon Athletica (LULU)	2005-2012	509.84%
Tyler Technologies (TYL)	2005-2012	478.04%
Cummins (CMI)	2005-2012	477.63%
Amazon (AMZN)	2005-2012	456.87%
Johnson Controls International (JCI)	2005-2012	383.87%
Tractor Supply (TSCO)	2005-2012	382.32%
Domino's Pizza Inc Common Stock (DPZ)	2005-2012	371.6%
Warner Bros Discovery (WBD)	2005-2012	337.93%
Edwards Lifesciences (EW)	2005-2012	337.09%
Union Pacific (UNP)	2005-2012	330.33%
Dollar Tree (DLTR)	2005-2012	318.87%