Marker Therapeutics (MRKR) had the highest return between 2000 and 2002 by a US stock, returning 4,877,948.8%.

ASSET	YEARS	% RETURN
Marker Therapeutics (MRKR)	2000-2002	4,877,948.78%
Live Ventures (LIVE)	2000-2002	228,685.94%
Thomson Reuters Corporation Common Shares (TRI)	2000-2002	21,947.42%
Inseego (INSG)	2000-2002	16,066.67%
Interlink Electronics (LINK)	2000-2002	7,564.22%
Alto Ingredients (ALTO)	2000-2002	5,319.58%
Gladstone Capital (GLAD)	2000-2002	2,982.68%
Flexible Solutions International (FSI)	2000-2002	2,774.7%
Nocera (NCRA)	2000-2002	2,354.55%
Versus Systems Inc. (VS)	2000-2002	1,900%
Flotek Industries (FTK)	2000-2002	1,453.85%
MEDIFAST (MED)	2000-2002	1,447.14%
Clean Harbors (CLH)	2000-2002	1,176.67%
FTI Consulting (FCN)	2000-2002	1,104.51%
DeFi Technologies (DEFT)	2000-2002	900%
Emerson Radio (MSN)	2000-2002	783.64%
Caledonia Mining (CMCL)	2000-2002	700.06%
CarMax (KMX)	2000-2002	694.67%
Algorhythm (RIME)	2000-2002	620%
Royal Gold (RGLD)	2000-2002	614.62%
NVR (NVR)	2000-2002	583.77%
American Vanguard (AVD)	2000-2002	535.66%
Eldorado Gold (EGO)	2000-2002	533.92%
Meritage (MTH)	2000-2002	526.06%
BJs Restaurants (BJRI)	2000-2002	481.08%