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best performing stocks 2012 with market cap above 1 billion

Seaport Therapeutics, Inc Common Stock (SPTX) has had the highest return since January 1, 2026 by a US stock with a market cap of $1B+, returning 232,700%.

ASSET% RETURN
Seaport Therapeutics, Inc Common Stock (SPTX)
232,700%
Mega Fortune Company Limited Ordinary Shares (MGRT)
1,557.97%
Sandisk (SNDK)
592.69%
agilon health (AGL)
428.09%
Moderna (MRNA)
358%
Aehr Test Systems (AEHR)
346.29%
Erasca (ERAS)
332.08%
10X Genomics (TXG)
306.99%
Twist Bioscience (TWST)
299.78%
Dell Technologies (DELL)
298.17%
Pulse Biosciences (PLSE)
293.56%
MaxLinear (MXL)
288.9%
Immunitybio (IBRX)
282.18%
Anterix (ATEX)
279.94%
AXT (AXTI)
276.16%
Enliven Therapeutics (ELVN)
262.77%
Eton Pharmaceuticals (ETON)
242.89%
Bandwidth (BAND)
232.39%
Micron Technology (MU)
231.37%
Kosmos Energy (KOS)
221.91%
Corcept Therapeutics (CORT)
221.36%
Hyperliquid Strategies Inc Common Stock (PURR)
211.9%
Seagate Technology (STX)
206.58%
Abcellera Biologics  (ABCL)
205.85%
Sellas Life Sciences (SLS)
203.15%

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